静止代谢速率是血浆中脂联素浓度一个重要预报值：与肥胖相关的失调的潜在暗示
美国临床营养杂志 2005 82: 21-25.
背景：我们对脂联素的调节了解不多。动物研究暗示：脂联素受到脂肪细胞因子或能量消耗改变的局部调节；人类研究暗示脂联素受到酒精摄入和种族划分的调节。
目的：为了确定人类脂联素的调节剂，我们对457名患有超重或肥胖的白人患者测量了静止代谢速率(RMR)、血浆中脂联素、葡萄糖、胰岛素、甘油三脂、酒精摄入和人体测量指数。
设计：我们使用了横断面研究，并以脂联素作为随变量，潜在的预报值作为主变量进行了多变量回归分析。
结果：单线性分析显示：脂联素和性别显著相关，标准系数为-0.38（女性和男性比较）以及解释了模型(R2)变异14%；年龄（0.21；4%）；静止代谢速率（RMR） (–0.52； 27%); 去脂体重(–0.40; 16%)； 脂肪体重 (–0.16；2%); 内脏脂肪 (–0.24; 6%； 对L4–L5的计算机X线断层摄影术)； 空腹甘油三脂 (–0.28; 8%)； 和胰岛素抵抗(–0.38; 14%; 动态平衡模型评估)。 脂联素和酒精不相关(–0.04; 0%)。 允许校正混杂的多变量分析显示：静止代谢速率（RMR）是脂联素最重要的预报值(–0.31; 29%)，然后依次是胰岛素抵抗(–0.16; 31%；包括静止代谢速率（RMR）和胰岛素抵抗的模型), 脂肪体重(0.20；34%)， 年龄 (0.34；35%)，内脏脂肪(–0.34；40%)，和空腹甘油三脂(–0.12；41%)。
结论：低静止代谢速率和血浆中高水平的脂联素相关。我们推测具有低静止代谢速率的人在理论上患有与肥胖相关的失调风险很高，这些人会受到脂联素的特殊保护。
关键词： 基础代谢 脂联素 肥胖 代谢综合症X 胰岛素抵抗 身体构造
Reference:
Resting metabolic rate is an important predictor of serum adiponectin concentrations: potential implications for obesity-related disorders
Am J Clin Nutr 2005 82: 21-25.
Johannes B Ruige, Dominique P Ballaux, Tohru Funahashi, Ilse L Mertens, Yuji Matsuzawa and Luc F Van Gaal
Background: Little is known about the regulation of adiponectin. Animal studies suggest local regulation by adipocytokines or alterations in energy expenditure, and studies in humans suggest regulation by alcohol intake and ethnicity.
Objective: To identify regulators of adiponectin in humans, we measured resting metabolic rate (RMR), serum adiponectin, glucose, insulin, triacylglycerol, alcohol intake, and anthropometric indexes in 457 white patients with overweight or obesity.
Design: A cross-sectional design was used, and multivariate regression analysis was performed with adiponectin as the dependent variable and potential predictors as independent variables.
Results: Simple linear analyses showed significant associations between adiponectin and sex, with a standardized coefficient of –0.38 (women compared with men) and an explanation of variation of the model (R2) of 14%; age (0.21; 4%); RMR (–0.52; 27%); fat-free mass (–0.40; 16%); fat mass (–0.16; 2%); visceral fat (–0.24; 6%; computed tomography at L4–L5); fasting triacylglycerol (–0.28; 8%); and insulin resistance (–0.38; 14%; homeostasis model assessment). Adiponectin and alcohol were not associated (–0.04; 0%). Multivariate analyses, which allowed adjustment for confounding, showed that RMR is the most important predictor of adiponectin (–0.31; 29%), followed successively by insulin resistance (–0.16; 31%; model containing RMR and insulin resistance), fat mass (0.20; 34%), age (0.34; 35%), visceral fat (–0.34; 40%), and fasting triacylglycerol (–0.12, 41%).
Conclusions: Low resting metabolism (RMR) is associated with high serum adiponectin. We speculate that subjects with low RMR, who are theoretically at greater risk of obesity-related disorders, are especially protected by adiponectin.
Key Words: Basal metabolism • adiponectin • obesity • metabolic syndrome X • insulin resistance • body constitution
美国哈佛大学公共卫生学院营养专业的Pischon说：“脂联素是一种来自脂肪细胞的肽，它参与调节胰岛素敏感性及脂质的氧化。脂联素与传统的心血管危险因素，如血压、心率及总胆固醇、低密度脂蛋白LDL?胆固醇及甘油三酯水平呈负相关，而与高密度脂蛋白HDL胆固醇水平正相关。最近有研究提示，脂联素可能有抗动脉粥样硬化及抗炎作用。血浆脂联素水平高的人患冠心病CHD的危险可能低。
本文确定了低静止代谢速率和血浆中高水平的脂联素相关，而低静止代谢速率的人患有与肥胖相关的失调风险很高。因此可以得出这样的结论：肥胖者如果静止代谢速率低，那么他体内的血浆脂联素水平就会较高，这样患冠心病的危险就会下降。
