Br J Haematol 2011 Nov;155 (3): 298-307. [IF:4.942]
microRNA regulation in megakaryocytopoiesis.
Li H , Zhao H , Wang D , Yang R .
State Key Laboratory of Experimental Haematology, Institute of Haematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
中国医学科学院血液病医院，实验血液学国家重点实验室，中国医学科学院北京协和医学院
Abstract
Megakaryocytopoiesis is governed by a complex network of haematopoietic growth factors that regulate the different stages of the process, in which haematopoietic stem cells undergo megakaryocytic lineage commitment, proliferation, maturation, and functional activation to produce platelets. MicroRNAs (miRNA) are a class of about 22-nucleotide noncoding RNAs that have been highly conserved during evolution and play a significant role in haematopoiesis, including differentiation and lineage commitment of megakaryocyte. This review summarizes the miRNAs which have changed expression during megakaryocytopoiesis, and their positive and negative functions on megakaryocytic differentiation. In addition, the abnormal miRNA expression profiles in megakaryocytic disorders are reviewed.
