李益明,男,主任医师,教授,博士生导师,现任复旦大学附属华山医院内分泌科主任。现任中华医学会内分泌分会垂体学组在组长,肾上腺学组、肥胖学组委员,中国垂体瘤协作组成员,上海医学会糖尿病分会副主任委员,上海市康复协会糖尿病分会副主任委员,上海市中医药学会糖尿病分会副主任委员、上海市中西医结合学会内分泌代谢病专业委员会副主任委员,国家食品药品监督管理局新药评审专家,国家自然科学基金评审专家,卫生部合理用药专家委员会委员。《中华糖尿病杂志》、《中国糖尿病杂志》编委。
专长及研究方向
神经内分泌疾病,垂体-下丘脑疾病及其术后功能随访,肥胖症及生长发育异常,糖尿病及慢性并发症,各种甲状腺疾病,特别是内分泌突眼及妊娠期甲状腺疾病的诊治。
教育经历
1991-1996 原上海医科大学研究生院 博士学位
1983-1988 江西医学院医疗系 学士学位
工作经历
2010- 今 复旦大学附属华山医院内分泌科 主任
2006- 今 复旦大学附属华山医院内分泌科 主任医师
1999-2006 复旦大学附属华山医院内分泌科 副教授
1996-1999 原上海医科大学附属华山医院内分泌科 主治医师
1988-1991 江西医学院第二附属医院内科 住院医生
社会兼职
中华医学会内分泌分会垂体学组在组长
中华医学会内分泌分会肾上腺学组委员
中华医学会内分泌分会肥胖学组委员
中国垂体瘤协作组成员
上海医学会糖尿病分会副主任委员
上海市康复协会糖尿病分会副主任委员
上海市中医药学会糖尿病分会副主任委员
上海市中西医结合学会内分泌代谢病专业委员会副主任委员
国家食品药品监督管理局新药评审专家
国家自然科学基金评审专家
卫生部合理用药专家委员会委员
《中华糖尿病杂志》编委
《中国糖尿病杂志》编委
奖励和荣誉
上海市优秀博士生论文,导师,2014
复旦大学教学成果奖,2012
复旦大学教学成果奖,2010
复旦大学精品课程,2007
发表论文 (第一作者及通讯作者)
1. The effect of zipper-interacting protein kinase on high glucose-stimulated human aortic smooth muscle cells. Ye Z, Wu W, He M, Leong M, Hu R, *Li Y, Zhang S. International Journal of Molecular Medicine 33(5), pp 1305-1311, 2014/5 (IF = 1.88).
2. Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes. Xue R, Wan Y, Zhang S, Zhang Q, Ye H, *Li Y. Am J Physiol Endocrinol Metab. 2014 Feb;306(4):E363-72. (IF = 4.514).
3. The prevalence and predictors of active brown adipose tissue in Chinese adults.Zhang Z, Cypess AM, Miao Q, Ye H, Liew CW, Zhang Q, Xue R, Zhang S, Zuo C, Xu Z, Tang Q, Hu R, Guan Y, *Li Y. Eur J Endocrinol. 2014 Feb 4;170(3):359-66. (IF = 3.136).
4. Differences in the metabolic status of healthy adults with and without active brown adipose tissue. Zhang Q, Ye H, Miao Q, Zhang Z, Wang Y, Zhu X, Zhang S, Zuo C, Zhang Z, Huang Z, Xue R, Zeng M, Huang H, Jin W, Tang Q, Guan Y, *Li Y. Wien Klin Wochenschr. 2013 Nov;125(21-22):687-95. (IF = 0.813).
5. Determination of Peripheral Neuropathy Prevalence and Associated Factors in Chinese Subjects with Diabetes and Pre-Diabetes – ShangHai Diabetic neuRopathy Epidemiology and Molecular Genetics Study (SH-DREAMS). Lu B, Hu J, Wen J, Zhang Z, Zhou L, *Li Y, Hu R. PLoS One. 2013 Apr 16;8(4):e61053 (IF = 3.730).
6. Fasting Capillary Blood Glucose: An Appropriate Measurement in Screening for Diabetes and Pre-diabetes in Low-Resource Rural Setting. Zhao X, Zhao W, Zhang H, Li J, Shu Y, Li S, Cai L, Zhou J, *Li Y, Hu R. J Endocrinol Invest. 2013 Jan;36(1):33-7.
7. Research on the relationships between pancreatic cancer and hyperglycemia in Chinese populations. Shan Huang, Hongying Ye, Wei Wu, Cheng Chen, Ji Li, Deliang Fu, *Yiming Li. Journal of Diabetes Investigation Volume 4 Issue 1 January 2013.
8. Decrease in Proportion of CD19(+)CD24(hi)CD27(+) B Cells and Impairment of Their Suppressive Function in Graves' Disease. Zha, Bingbing; Wang, Luman; Liu, Xiaoming; Liu, Jun; Chen, Zaoping; Xu, Jiong; *Sheng, Li; Li, Yiming; Chu, Yiwei,. PLOS ONE, 2012, 7(11) :e49835 (IF = 3.730) .
9. Peak Systolic Velocity of Superior Thyroid Artery for the Differential Diagnosis of Thyrotoxicosis. Zhao, Xiaolong; Chen, Lili; Li, Ling; Wang, Yao; Wang, Yong; Zhou, Linuo; Zeng, Fangfang; *Li, Yiming; Hu, Renming; Liu, Hong. PLOS ONE, 2012, 7(11) :e50051 (IF = 3.730) .
10. Prevalence of diabetes and predictions of its risks using anthropometric measures in southwest rural areas of China, Zhao, Xiaolong; Zhu, Xiaoming; Zhang, Hengsheng; Zhao, Weiwei; Li, Jinhui; Shu, Yonghui; Li, Songwu; Yang, Minghui; Cai, Linghu; Zhou, Jiping; *Li, Yiming. BMC PUBLIC HEALTH, 2012, 12, 821 (IF = 2.076) .
11. Stability in Brain Glucose Metabolism Following Brown Adipose Tissue Inactivation in Chinese Adults. Miao, Q.; Zhao, X. L.; Zhang, Q. Y.; Zhang, Z. Y.; Guan, Y. H.; Ye, H. Y.; Zhang, S.; Zeng, M. F.; *Zuo, C. T.; *Li, Y. M. American Journal Of Neuroradiology, 2012, 33(8), pp 1464-1469 (IF = 3.167) .
12. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Wang Y; Cheng KK; Lam KS; Wu D; Wang Y; Huang Y; Vanhoutte PM; Sweeney G; *Li Y; Xu A. Diabetes, 2011, 60(11), pp 3044-3054 (IF = 8.889) .
13. Reversible changes in brain glucose metabolism following thyroid function normalization in hyperthyroidism. Q.Miao; S.Zhang; Y.H.Guan; H.Y.Ye; Z.Y.Zhang; Q.Y.Zhang; R.D.Xue; M.F.Zeng; C.T.Zuo; *Y.M.Li. Am J Neuroradiol, 2011, 32(6), pp 1034-1042 ((IF = 3.296) .
14. Exercise improved rat metabolism by raising PPAR-α. Zhang S; Liu Y; Li Q; Dong X; Hu H; Hu R; Ye H; Wu Y; *Li Y. Int J Sports Med. 2011 Aug;32(8):568-73. (IF = 2.433) .
15. Chen W, Yu MH, Li YM*, Chen WJ, Xia YP. Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters. Acta Diabetol. 2009 Apr 7. [Epub ahead of print].
16. Chen W, Li YM*, Yu MH. Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation. J Diabetes Complications. 2009 Feb 18. [Epub ahead of print].
17. Chen W, Li YM*, Yu MH. Effects of Astragalus Polysaccharides on Chymase, Angiotensin-Converting Enzyme and Angiotensin II in Diabetic Cardiomyopathy in Hamsters。The Journal of International Medical Research。0300-0605。2007;35(6);873-877.
18. Chen W, Li YM*, Yu MH. Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice.Exp Clin Endocrinol Diabetes. 2008 ;116(8):468-474.
19. 陈蔚,李益明,俞茂华,等。黄芪多糖对糖尿病鼠 T 细胞亚群的免疫调节作用。中国现代医学杂志。2007,17(1):28-31.
20. 陈蔚,俞茂华,李益明,等。黄芪多糖对非肥胖糖尿病鼠胰岛超微结构及氧化凋亡因子表达的影响。复旦学报(医学版)。2007,34(2):269-272.
21. 丛丽,李益明:黄芪多糖对糖尿病心肌病变仓鼠心肌胶原表达的影响。中国临床康复。2006,10(7):64-66.
22. 陈蔚,李益明,俞茂华,等。黄芪多糖影响 NOD 小鼠胰岛超微结构及胰腺 Th1/Th2 型细胞因子表达。中华内分泌代谢杂志。2007,23(3):269-273.
23. 裴宁,李益明:罗格列酮与二甲双胍对 2 型糖尿病心血管病变危险因素的干预效果比较. 临床内科杂志.2006, 23(5): 346-347.
24. 裴宁; 张烁; 李益明; 焦东海: 大黄提取片改善单纯性肥胖患者胰岛素敏感性的研究. 中国临床医学, 2006,13(3):439-442.
25. 张烁,李益明:人脂联素受体 1 和 2 的真核表达。 复旦学报(医学版)。2006,33(6):845-847.
26. 查兵兵,李益明:大黄提取片对高脂饮食诱导肥胖大鼠能量代谢的影响。上海中医药杂志。2006,40(10):57-59.
27. 查兵兵,李益明:大黄提取片对高脂饮食诱导肥胖大鼠脂代谢及相关基因表达的影响。中华中医药杂志。2006,21(10):585-588.
28. 丛丽,李益明:糖尿病仓鼠心肌糜蛋白酶和血管紧张素转换酶基因表达的变化. 中华糖尿病杂志.2005, 13(6): 459-462.